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. 2010 May 3;11(3):298-302.
doi: 10.3109/17482961003605788.

Cognitive and behavioral challenges in caring for patients with frontotemporal dementia and amyotrophic lateral sclerosis

Jennifer Merrilees  1 , Jennifer Klapper, Jennifer Murphy, Catherine Lomen-Hoerth, Bruce L Miller
Affiliations

Cognitive and behavioral challenges in caring for patients with frontotemporal dementia and amyotrophic lateral sclerosis

Jennifer Merrilees et al. Amyotroph Lateral Scler. .

Abstract

Frontotemporal dementia (FTD) is a progressive neurological condition caused by degeneration of the frontal and/or anterior temporal lobes resulting in personality, behavioral, and cognitive changes. Amyotrophic lateral sclerosis (ALS) is caused by degeneration of lower motor and pyramidal neurons, leading to loss of voluntary muscle movement. The common molecular pathological and anatomical overlaps between FTD and ALS suggest that the two disorders are strongly linked. In some patients FTD precedes ALS; in others ALS occurs first, while in still others the two disorders begin simultaneously. The association between ALS and FTD creates unique challenges for family caregivers. This paper provides a guide for healthcare providers caring for patients with FTD-ALS exhibiting behavioral, cognitive, and emotional symptoms. Strategies are suggested to help minimize the impact of negative symptoms.

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Conflict of interest statement

Declaration on interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

References

    1. Bathgate D, Snowden JS, Varma A, Blackshaw A, Neary D. Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia. Acta Neurol Scand. 2001 Jun;103(6):367–78. - PubMed
    1. Rosen HJ, Allison SC, Schauer GF, Gorno-Tempini ML, Weiner MW, Miller BL. Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005 Nov;128(Pt 11):2612–25. - PMC - PubMed
    1. Murphy JM, Henry RG, Langmore S, Kramer JH, Miller BL, Lomen-Hoerth C. Continuum of frontal lobe impairment in amyotrophic lateral sclerosis. Arch Neurol. 2007 Apr;64(4):530–4. - PubMed
    1. Rosen HJ, Gorno-Tempini ML, Goldman WP, Perry RJ, Schuff N, Weiner M, et al. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology. 2002 Jan 22;58(2):198–208. - PubMed
    1. Murphy J, Henry R, Lomen-Hoerth C. Establishing subtypes of the continuum of frontal lobe impairment in amyotrophic lateral sclerosis. Arch Neurol. 2007 Mar;64(3):330–4. - PubMed

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