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Comment
. 2010 Mar 11;65(5):577-9.
doi: 10.1016/j.neuron.2010.02.026.

Oligodendrocytes and the "micro brake" of progenitor cell proliferation

Klaus-Armin Nave  1
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Oligodendrocytes and the "micro brake" of progenitor cell proliferation

Klaus-Armin Nave. Neuron. .
Free article

Abstract

A large fraction of mammalian genes is regulated posttranscriptionally by microRNAs. In the developing nervous system, a small subset of these short RNA molecules is important to orchestrate the rapid switch from OPCs to myelin-forming oligodendrocytes. But putting the miRNA brake on oligodendrocyte gene expression is required throughout life.

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