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Multicenter Study
. 2010 Mar;3(3):266-74.
doi: 10.1016/j.jcmg.2009.10.012.

The impact of obesity on the left ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA)

Evrim B Turkbey  1 , Robyn L McClelland, Richard A Kronmal, Gregory L Burke, Diane E Bild, Russell P Tracy, Andrew E Arai, João A C Lima, David A Bluemke
Affiliations
Multicenter Study

The impact of obesity on the left ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA)

Evrim B Turkbey et al. JACC Cardiovasc Imaging. 2010 Mar.

Abstract

Objectives: The purpose of this study was to evaluate the relationship of left ventricular (LV) remodeling assessed by cardiac magnetic resonance to various measures of obesity in a large population-based study.

Background: Obesity is a well-known risk factor for cardiovascular disease, yet its relationship with LV size and function is poorly understood.

Methods: A total of 5,098 participants (age 45 to 84 years; 48% men) in the Multi-Ethnic Study of Atherosclerosis who were free of clinically apparent cardiovascular disease underwent cardiac magnetic resonance to assess LV size and function as well as measures of obesity, including body mass index, waist-to-hip ratio and waist circumference, and cardiovascular risk factors. Fat mass (FM) was estimated based on height-weight models derived from bioelectrical impedance studies. The associations of obesity measures with LV size and function were evaluated using linear spline regression models for body mass index and multivariable regression models for other measures of obesity; they were displayed graphically using generalized additive models.

Results: LV mass and end-diastolic volume were positively associated with measures of obesity in both sexes after adjustment for risk factors (e.g., 5.7-g and 6.9-g increase in LV mass per 10-kg increase in FM in women and men, respectively [p < 0.001]). LV mass-to-volume ratio was positively associated with increased body mass index, waist-to-hip ratio, waist circumference, and estimated FM (e.g., 0.02-g/ml and 0.06-g/ml increase in mass-to-volume ratio per 10-kg increase in FM in women and men, respectively [p < 0.001]). The increased mass-to-volume ratio was due to a greater increase in LV mass relative to LV end-diastolic volume. All associations were stronger for men than for women. Ejection fraction showed no significant association with measures of obesity.

Conclusions: Obesity was associated with concentric LV remodeling without change in ejection fraction in a large, multiethnic cohort study.

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Figures

Figure 1
Figure 1. Association of BMI With LV Parameters
Generalized additive models representing the association of body mass index (BMI) with left ventricular (LV) mass (A), end-diastolic volume (B), mass-to-volume ratio (C), and ejection fraction (D) after adjustment for risk factors. Fully adjusted models per Table 4. The color lines represent the mean values of LV parameters and the dashed lines represent 95% confidence intervals.
Figure 2
Figure 2. Association of FM With LV Parameters
Generalized additive models representing the association of fat mass (FM) with left ventricular (LV) mass (A), volume (B), mass-to-volume ratio (C), and ejection fraction (D) after adjustment for risk factors. Fully adjusted models per Table 4. The color lines represent the mean values of LV parameters and the dashed lines represent 95% confidence intervals.
See this image and copyright information in PMC

Comment in

References

    1. Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006;113:898–918. - PubMed
    1. Vasan RS. Cardiac function and obesity. Heart. 2003;89:1127–9. - PMC - PubMed
    1. Lauer MS, Anderson KM, Kannel WB, Levy D. The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study. JAMA. 1991;266:231–6. - PubMed
    1. Peterson LR, Waggoner AD, Schechtman KB, et al. Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. J Am Coll Cardiol. 2004;43:1399–404. - PubMed
    1. Chuang ML, Danias PG, Riley MF, Hibberd MG, Manning WJ, Douglas PS. Effect of increased body mass index on accuracy of two-dimensional echocardiography for measurement of left ventricular volume, ejection fraction, and mass. Am J Cardiol. 2001;87:371–4. A10. - PubMed

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