Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?

Abstract

Objective: We sought to determine allele frequencies of 3 LAMC1 single nucleotide polymorphisms (SNPs) in Caucasian and African American (AA) women with stage>II pelvic organ prolapse (POP) (cases) and in ethnicity-matched controls with stage<II POP. We also sought to determine if LAMC1 is associated with POP within ethnic groups.

Study design: Allelic discrimination was performed for LAMC1 SNPs rs10911193 (C/T), rs20563 (A/G), and rs20558 (T/C). SNP and haplotype-specific tests were used to examine associations among POP, ethnicity, and LAMC1.

Results: In all, 411 women were enrolled. Significant differences in allele and haplotype frequencies existed among AAs and Caucasians: rs10911193 "T" (P=.0014); rs20563 "G" (P<.0001); rs20558 "C" (P<.0001); rs20563, rs20558 "GC" (P<.0001); and rs20563, rs20558 "AT" (P<.0001). No significant associations between POP and LAMC1 SNPs or haplotypes were found within ethnicities.

Conclusion: While significant differences were identified between AA and Caucasian women, no associations were found between any LAMC1 gene variant and advanced POP.

Figure 1

Linkage disequilibrium (LD) plots with inter-single nucleotide polymorphism (SNP) R² for LAMC1 SNPs rs10911193, rs20563, and rs20558 within the African American and Caucasian cohorts.