Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 May;202(5):505.e1-5.
doi: 10.1016/j.ajog.2010.01.014. Epub 2010 Mar 12.

Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?

Chen Chen  1 , Lori D Hill, Christine M Schubert, Jerome F Strauss 3rd, Catherine A Matthews
Affiliations

Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?

Chen Chen et al. Am J Obstet Gynecol. 2010 May.

Abstract

Objective: We sought to determine allele frequencies of 3 LAMC1 single nucleotide polymorphisms (SNPs) in Caucasian and African American (AA) women with stage>II pelvic organ prolapse (POP) (cases) and in ethnicity-matched controls with stage<II POP. We also sought to determine if LAMC1 is associated with POP within ethnic groups.

Study design: Allelic discrimination was performed for LAMC1 SNPs rs10911193 (C/T), rs20563 (A/G), and rs20558 (T/C). SNP and haplotype-specific tests were used to examine associations among POP, ethnicity, and LAMC1.

Results: In all, 411 women were enrolled. Significant differences in allele and haplotype frequencies existed among AAs and Caucasians: rs10911193 "T" (P=.0014); rs20563 "G" (P<.0001); rs20558 "C" (P<.0001); rs20563, rs20558 "GC" (P<.0001); and rs20563, rs20558 "AT" (P<.0001). No significant associations between POP and LAMC1 SNPs or haplotypes were found within ethnicities.

Conclusion: While significant differences were identified between AA and Caucasian women, no associations were found between any LAMC1 gene variant and advanced POP.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Linkage disequilibrium (LD) plots with inter-single nucleotide polymorphism (SNP) R2 for LAMC1 SNPs rs10911193, rs20563, and rs20558 within the African American and Caucasian cohorts.
See this image and copyright information in PMC

References

    1. Chiaffarino F, et al. Reproductive factors, family history, occupation and risk of urogenital prolapse. Eur J Obstet Gynecol Reprod Biol. 1999;82(1):63–67. - PubMed
    1. Mant J, Painter R, Vessey M. Epidemiology of genital prolapse: observations from the Oxford Family Planning Association Study. Br J Obstet Gynaecol. 1997;104(5):579–585. - PubMed
    1. Weber AM, Richter HE. Pelvic organ prolapse. Obstet Gynecol. 2005;106(3):615–634. - PubMed
    1. Bump RC, Norton PA. Epidemiology and natural history of pelvic floor dysfunction. Obstet Gynecol Clin North Am. 1998;25(4):723–746. - PubMed
    1. Nygaard I, Bradley C, Brandt D. Pelvic organ prolapse in older women: prevalence and risk factors. Obstet Gynecol. 2004;104(3):489–497. - PubMed

Publication types