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Case Reports
. 2010 Feb 5;3(3):319-22.

Sarcomatoid carcinoma of the prostate: a case report

Adamantia Zizi-Sermpetzoglou  1 , Vassiliki Savvaidou, Nikolaos Tepelenis, Nikolaos Galariotis, Michalis Olympitis, Konstantinos Stamatiou
Affiliations
Case Reports

Sarcomatoid carcinoma of the prostate: a case report

Adamantia Zizi-Sermpetzoglou et al. Int J Clin Exp Pathol. .

Abstract

Sarcomatoid carcinoma of the prostate is a rare variant of prostatic cancer, with less than 100 cases reported in the literature up to date. Tumors are most commonly composed of an admixture of both malignant glandular and spindle cell elements. The sarcomatoid component can vary from 5 to 99%. We report a case of a 76-year old Caucasian man who underwent transurethral resection of the prostate for the treatment of bladder outlet obstruction. Histopathologic examination revealed a tumor with malignant epithelial and sarcomatous elements. The malignant epithelial component consisted of poorly differentiated adenocarcinoma (Gleason score 5+4=9/10) and the sarcomatous component was mainly composed of undifferentiated spindle cells. On immunohistochemistrythe latter expressed a positive staining for vimentin. Several cells were positively stained for cytockeratin AE3 and myoD1 while all were negative for actin, desmin and myogenin. The diagnosis of sarcomatoid carcinoma was finally made. Although sarcomatoid carcinoma of the prostate is a highly aggressive neoplasm and patients have a poor prognosis, our patient is still alive one year after diagnosis.

Keywords: Prostate cancer; carcinosarcoma; cytokeratin AE1/3; immunohistochemistry; sarcomatoid carcinoma; vimentin.

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Figures

Figure 1
Figure 1
Poorly differentiated adenocarcinoma of the prostate (H&E×20).
Figure 2
Figure 2
Spindle shaped pleomorphic neoplasm (H&E×20).
Figure 3
Figure 3
Prostate carcinoma expressing PSAP (PSAP×20).
Figure 4
Figure 4
Spindle cells expressing vimentin (VIM×40).
Figure 5
Figure 5
A few spindle giant cells positively stained for CKAE3 (CKAE3×40).
Figure 6
Figure 6
Several spindle giant cells positively stained for MyoD1 (MyoD1×40).
See this image and copyright information in PMC

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