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Comparative Study
. 2010 Jun;12(2):238-41.
doi: 10.1208/s12248-010-9176-2. Epub 2010 Mar 12.

Comparison of drug permeabilities and BCS classification: three lipid-component PAMPA system method versus Caco-2 monolayers

Zeynep S Teksin  1 , Paul R Seo, James E Polli
Affiliations
Comparative Study

Comparison of drug permeabilities and BCS classification: three lipid-component PAMPA system method versus Caco-2 monolayers

Zeynep S Teksin et al. AAPS J. 2010 Jun.
No abstract available

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Figures

Fig. 1
Fig. 1
Comparison between Caco-2 permeability and PAMPA permeability. The PAMPA membrane included and an anionic component, such that this system is denoted A-PAMPA. In general, high permeability in PAMPA corresponded with high permeability across Caco-2 monolayers
Fig. 2
Fig. 2
Plots of human percent dose absorbed versus A-PAMPA permeability and Caco-2 permeability. For each of the 20 compounds, A-PAMPA permeability was generally less than corresponding Caco-2 permeability, typically by several-fold
See this image and copyright information in PMC

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References

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