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. 2011 Aug;21(8):546-52.
doi: 10.1016/j.numecd.2009.12.002. Epub 2010 Mar 15.

Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians

J R Shaffer  1 , C M Kammerer, J Dorn, R E Ferrell, L Iacoviello, M Trevisan, R P Donahue
Affiliations

Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians

J R Shaffer et al. Nutr Metab Cardiovasc Dis. 2011 Aug.

Abstract

Background and aims: Glycoprotein 6 (GP6) is a platelet-specific collagen receptor implicated in the thrombotic pathway to acute myocardial infarction (AMI), but a possible genetic relationship between GP6 and AMI is poorly understood. We tested for the genetic association between AMI and single nucleotide polymorphisms (SNPs) in 24 loci, including GP6.

Methods and results: We conducted a case-control study of AMI and GP6 in a community-based population (n = 652 cases, 625 controls). We also examined men and women separately and stratified the latter by use of hormone replacement therapy (HRT). Among both sexes, the strongest association was for a protective missense polymorphism (rs1163662) in the GP6 gene (OR = 0.70; Bonferroni-adjusted p < 0.05). SNPs in GP6 were also strongly associated with AMI among women who reported ever taking HRT, but not among women who never took HRT. Haplotype analyses were consistent with the single-SNP findings.

Conclusions: In this sample of white non-Hispanic men and women, several SNPs in GP6 were significantly related to risk of AMI. Development of pharmacologic therapy directed towards platelet activity and thrombosis may reduce the incidence of AMI among at-risk groups.

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Conflict of interest statement

Conflicts of Interest

All authors declare no conflicts of interest related to this work.

Figures

Figure 1
Figure 1. Linkage disequilibrium (r2) between polymorphisms in the GP6 gene
Positions of SNP markers in the GP6 gene are indicated and annotated as missense (i.e. exonic non-synonymous), intronic, or the 3′ untranslated region. Linkage disequilibrium among these SNPs is shown in the heat map.
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