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doi: 10.1016/j.chom.2010.03.001.
The HIV-1 Tat team gets bigger
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- PMID: 20227660
- DOI: 10.1016/j.chom.2010.03.001
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The HIV-1 Tat team gets bigger
Cell Host Microbe.
.
Free article
Abstract
Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.Cell Host Microbe. 2010 Mar 18;7(3):234-44. doi: 10.1016/j.chom.2010.02.005. Cell Host Microbe. 2010. PMID: 20227666 Free PMC article.
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