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Review
. 2010 Jan 26;2(1):69-73.
doi: 10.18632/aging.100118.

Aging: Dial M for Mitochondria

Jae H Hur  1 , Jaehyoung Cho, David W Walker
Affiliations
Review

Aging: Dial M for Mitochondria

Jae H Hur et al. Aging (Albany NY). .

Abstract

A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. We performed an RNAi screen to probe the role of ETC components in modulating lifespan in the fruit fly Drosophila melanogaster. In this Research Perspective, we discuss our findings and how they may relate to similar studies in worms and mice.

Keywords: C. elegans; Drosophila; longevity; respiratory chain.

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Conflict of interest statement

The authors of this manuscript have no conflict of interest to declare.

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