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. 2010 Jul;21(7):1033-46.
doi: 10.1007/s10552-010-9532-7. Epub 2010 Mar 14.

Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease

Xuefen Su  1 , Rulla M Tamimi, Laura C Collins, Heather J Baer, Eunyoung Cho, Laura Sampson, Walter C Willett, Stuart J Schnitt, James L Connolly, Bernard A Rosner, Graham A Colditz
Affiliations

Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease

Xuefen Su et al. Cancer Causes Control. 2010 Jul.

Abstract

Objective: We examined the association between adolescent fiber intake and proliferative BBD, a marker of increased breast cancer risk, in the Nurses' Health Study II.

Methods: Among 29,480 women who completed a high school diet questionnaire in 1998, 682 proliferative BBD cases were identified and confirmed by centralized pathology review between 1991 and 2001. Multivariate-adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results: Women in the highest quintile of adolescent fiber intake had a 25% lower risk of proliferative BBD (multivariate HR (95% CI): 0.75 (0.59, 0.96), p-trend = 0.01) than women in the lowest quintile. High school intake of nuts was also related to significantly reduced BBD risk. Women consuming >or=2 servings of nuts/week had a 36% lower risk (multivariate HR (95% CI): 0.64 (0.48, 0.85), p-trend < 0.01) than women consuming <1 serving/month. Results were essentially the same when the analysis was restricted to prospective cases (n = 142) diagnosed after return of the high school diet questionnaire.

Conclusions: These findings support the hypothesis that dietary intake of fiber and nuts during adolescence influences subsequent risk of breast disease and may suggest a viable means for breast cancer prevention.

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