News of cognitive cure for age-related brain shrinkage is premature: a comment on Burgmans et al. (2009)
- PMID: 20230118
- PMCID: PMC2841326
- DOI: 10.1037/a0018828
News of cognitive cure for age-related brain shrinkage is premature: a comment on Burgmans et al. (2009)
Abstract
The extant longitudinal literature consistently supports the notion of age-related declines in human brain volume. In a report on a longitudinal cognitive follow-up with cross-sectional brain measurements, Burgmans and colleagues (2009) claim that the extant studies overestimate brain volume declines, presumably due to inclusion of participants with preclinical cognitive pathology. Moreover, the authors of the article assert that such declines are absent among optimally healthy adults who maintain cognitive stability for several years. In this comment accompanied by reanalysis of previously published data, we argue that these claims are incorrect on logical, methodological, and empirical grounds.
Copyright 2010 APA, all rights reserved
Comment on
-
The prevalence of cortical gray matter atrophy may be overestimated in the healthy aging brain.Neuropsychology. 2009 Sep;23(5):541-50. doi: 10.1037/a0016161. Neuropsychology. 2009. PMID: 19702408
References
-
- Burgmans S, van Boxtel MP, Vuurman EF, Smeets F, Gronenschild EH, Uylings HB, Jolles J. The prevalence of cortical gray matter atrophy may be overestimated in the healthy aging brain. Neuropsychology. 2009;23:541–550. - PubMed
-
- De Toledo-Morrell L, Stoub TR, Bulgakova M, Wilson RS, Bennett DA, Leurgans S, Wuu J, Turner DA. MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiology of Aging. 2004;25:1197–1203. - PubMed
-
- Hofer SM, Flaherty BP, Hoffman L. Cross-sectional analysis of time-dependent data: Mean-induced association in age-heterogeneous samples and an alternative method based on sequential narrow age-cohort samples. Multivariate Behavioral Resarch. 2006;41:165–187. - PubMed
