Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010;14(2):R33.
doi: 10.1186/cc8911. Epub 2010 Mar 15.

The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-alpha in critically ill patients: a prospective observational study

Ayman Abd Al-Maksoud Yousef  1 , Yasser Mohamed Amr, Ghada Abdulmomen Suliman
Affiliations
Comparative Study

The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-alpha in critically ill patients: a prospective observational study

Ayman Abd Al-Maksoud Yousef et al. Crit Care. 2010.

Abstract

Introduction: Severe infection and sepsis are common causes of morbidity and mortality. Early diagnosis in critically ill patients is important to reduce these complications. The present study was conducted to determine the role of serum leptin at early diagnosis and differentiation between patients with manifestations of systemic inflammatory response syndrome (SIRS) and those with sepsis in patients suffering from a broad range of diseases in the intensive care unit (ICU) and its correlation with other biomarkers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).

Methods: One hundred and six adult ICU patients were observed. CRP, leptin, IL-6 and TNF-alpha were compared among the following groups: sepsis group (n = 40), SIRS group (n = 34) and non-SIRS group (n = 32). Patients were classified into these groups at the time of blood analysis for these biomarkers.

Results: Non-significant differences were observed among patients in different groups regarding biomarkers on the day of ICU admission. On the second day of ICU admission, significant elevation of leptin, IL-6 and TNF-alpha occurred in the SIRS and sepsis groups. Delayed elevation of CRP started on the fourth day of ICU admission in patients with sepsis. At the end of the first week, only CRP level was elevated in septic patients.

Conclusions: Serum leptin correlates well with serum level of IL-6 and TNF-alpha. Leptin helps to differentiate SIRS from non-SIRS patients. CRP is a classic marker of sepsis but is of late onset.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Correlation between leptin and TNF-α in SIRS group. Significant positive correlation between leptin and TNF-α in SIRS group.
Figure 2
Figure 2
Correlation between leptin and TNF-α in sepsis group. Significant positive correlation between leptin and TNF-α in sepsis group.
Figure 3
Figure 3
Correlation between leptin and IL-6 in SIRS group. Significant positive correlation between leptin and IL-6 in SIRS group.
Figure 4
Figure 4
Correlation between leptin and IL-6 in sepsis group. Significant positive correlation between leptin and IL-6 in sepsis group.
Figure 5
Figure 5
Receiver operator curve of serum leptin between non-SIRS versus SIRS and sepsis groups.
Figure 6
Figure 6
Receiver operator curve of serum leptin between SIRS and sepsis groups.
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Arabi Y, AL Shirawi N, Memish Z, Venkatesh S, Al-Shimemeri A. Assessment of six mortality prediction models in patients admitted with severe sepsis and septic shock to the intensive care unit: a prospective cohort study. Crit Care. 2003;7:R116–122. doi: 10.1186/cc2373. - DOI - PMC - PubMed
    1. Monkhouse D. Postoperative sepsis. Current Anaesthesia and Critical Care. 2006;17:65–70. doi: 10.1016/j.cacc.2006.05.005. - DOI
    1. Crabtree TD, Pelletier SJ, Antevil JL, Gleason TG, Pruett TL, Sawyer RG. Cohort study of fever and leukocytosis as diagnostic and prognostic indicators in infected surgical patients. World J Surg. 2001;25:739–744. doi: 10.1007/s00268-001-0025-4. - DOI - PubMed
    1. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and sever trauma. Crit Care Med. 1997;25:1813–1819. doi: 10.1097/00003246-199711000-00018. - DOI - PubMed
    1. Chachkhiani I, Gurlich R, Maruna P, Frasko R, Lindner J. The postoperative stress response and its reflection in cytokines network and leptin plasma levels. Physiol Res. 2005;54:279–285. - PubMed

Publication types

MeSH terms