Comment
doi: 10.1016/j.devcel.2010.03.004.
Terminating histone synthesis to preserve centromere integrity
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- PMID: 20230740
- DOI: 10.1016/j.devcel.2010.03.004
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Terminating histone synthesis to preserve centromere integrity
Dev Cell.
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Free article
Abstract
Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disrupts centromeric chromatin structure.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.Dev Cell. 2010 Mar 16;18(3):385-96. doi: 10.1016/j.devcel.2009.12.024. Dev Cell. 2010. PMID: 20230746 Free PMC article.
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Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.Dev Cell. 2010 Mar 16;18(3):385-96. doi: 10.1016/j.devcel.2009.12.024. Dev Cell. 2010. PMID: 20230746 Free PMC article.
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