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Comment
. 2010 Mar 16;18(3):335-6.
doi: 10.1016/j.devcel.2010.03.004.

Terminating histone synthesis to preserve centromere integrity

William F Marzluff  1
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Terminating histone synthesis to preserve centromere integrity

William F Marzluff. Dev Cell. .
Free article

Abstract

Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disrupts centromeric chromatin structure.

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