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. 2010 May;23(1-2):77-80.
doi: 10.1016/j.trim.2010.03.002. Epub 2010 Mar 15.

Frequent expression of C4d in hepatic graft-versus-host disease: potential clue for diagnosis and distinguishing acute and chronic form

Sharif A Ali  1 , Veena Shah, Rick McKinnon, Meredith Van Harn, Nalini Janakiraman
Affiliations

Frequent expression of C4d in hepatic graft-versus-host disease: potential clue for diagnosis and distinguishing acute and chronic form

Sharif A Ali et al. Transpl Immunol. 2010 May.

Abstract

Background: Graft-versus-host disease (GVHD), a common complication of hematopoietic stem cell transplant, is generally regarded to develop through cell-mediated immune response following activation of helper T cells. Since production of antibodies is also mediated by helper T cells, the role of humoral immunity in GVHD is questioned and has not yet been explored in clinical practice. We conducted a pilot study to evaluate the role of antibody production in hepatic H-GVHD and whether it can distinguish acute and chronic forms.

Results: C4d expression was increased in portal vessels and hepatic sinusoids of patients with histological proven evidence of GVHD 11/16 (P=0.007). Patients classified as chronic GVHD were statistically more likely to have C4d expression in the portal vasculature and liver sinusoids (P=0.011).

Conclusion: Humoral activation seems to play a role in pathophysiology of hepatic, especially chronic GVHD.

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