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. 2010 May;54(5):2188-90.
doi: 10.1128/AAC.01603-09. Epub 2010 Mar 15.

In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria

Carmen A Molina-Torres  1 , Jorge Ocampo-Candiani, Adrian Rendón, Michael J Pucci, Lucio Vera-Cabrera
Affiliations

In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria

Carmen A Molina-Torres et al. Antimicrob Agents Chemother. 2010 May.

Abstract

In this work, we describe the activity of ACH-702 against clinical isolates of Mycobacterium tuberculosis and six different nontuberculous mycobacteria. The MIC(50) and MIC(90) of both susceptible and drug-resistant M. tuberculosis strains tested were 0.0625 and 0.125 microg/ml, respectively. The MIC(50) and MIC(90) values for Mycobacterium fortuitum isolates were 0.0625 microg/ml in both cases; Mycobacterium avium complex isolates showed MIC(50) and MIC(90) values of 0.25 and 4 microg/ml, respectively.

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