EGFR (trans)activation mediates IL-8 and distinct human antimicrobial peptide and protein production following skin injury
- PMID: 20231833
- DOI: 10.1038/jid.2009.371
EGFR (trans)activation mediates IL-8 and distinct human antimicrobial peptide and protein production following skin injury
Abstract
Antimicrobial peptides and proteins (AMPs) are tools of the innate immune system employed at injury sites to protect the host from invading microbes and to promote wound repair. In this issue, Roupé et al. characterize epidermal innate immune responses induced by skin injury and the involvement of EGFR for distinct AMPs and IL-8 induction.
Comment on
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Injury is a major inducer of epidermal innate immune responses during wound healing.J Invest Dermatol. 2010 Apr;130(4):1167-77. doi: 10.1038/jid.2009.284. Epub 2009 Sep 3. J Invest Dermatol. 2010. PMID: 19727116