doi: 10.1111/j.1535-7511.2009.01350.x.
Prenatal effects of antiepileptic drugs
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- PMID: 20231922
- PMCID: PMC2836476
- DOI: 10.1111/j.1535-7511.2009.01350.x
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Prenatal effects of antiepileptic drugs
Epilepsy Curr.
2010 Mar.
Abstract
Antiepileptic drugs (AEDs) target ion channels and neurotransmitter systems in the brain; these same targets are responsible for regulation of processes essential for brain development. In this review, experimental findings on adverse effects of AEDs in the developing mammalian brain will be presented, including interference with physiological apoptotic cell death, cell proliferation and migration, neurogenesis, axonal arborization, synaptogenesis, and synaptic plasticity.
Figures
Brain growth spurts in humans and rats, expressed as first-order velocity curves of the increase in weight with age. Reference: Ikonomidou and Turski (55).
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