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Comparative Study
. 2010 Apr;15(2):119-25.
doi: 10.1177/1358863X09358750.

Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers

Kevin S Heffernan  1 , Richard H Karas, Eshan A Patvardhan, Jeffrey T Kuvin
Affiliations
Comparative Study

Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers

Kevin S Heffernan et al. Vasc Med. 2010 Apr.

Abstract

Smoking is an established cardiovascular risk factor that impairs endothelial function and reduces exercise capacity. Peripheral vascular endothelial function correlates with exercise capacity, but whether this association prevails in smokers is unknown. The purpose of this investigation was to examine the association between endothelial function and exercise capacity in chronic smokers and non-smoking controls. Brachial artery flow-mediated dilation (FMD, endothelium-dependent) following 5 minutes of upper arm occlusion was compared in 26 smokers (age 58 +/- 2 years; 15 female; BMI (body mass index) = 28 +/- 1) and 39 non-smokers (age 58 +/- 2 years; 24 female; BMI = 28 +/- 1) using ultrasound. Exercise treadmill time (ETT) was recorded from a standard Bruce protocol during symptom limited stress testing. There was found to be a significant positive association between FMD and ETT in smokers (r = 0.60, p < 0.05) and non-smokers (r = 0.28, p < 0.05). FMD was significantly lower in smokers versus non-smokers (8.9 +/- 0.9 vs 12.6 +/- 0.7%, p < 0.05). ETT was significantly lower in smokers (425 +/- 35 seconds) versus non-smokers (522 +/- 25 seconds, p < 0.05). After adjusting for FMD, there were no longer group differences in ETT. When patients were matched according to FMD, there were no differences in ETT between smokers and non-smokers. In conclusion, peripheral endothelial dysfunction is a correlate of low exercise capacity in smokers and non-smokers alike. Future research is needed to examine if improving endothelial function will lead to concomitant increases in exercise capacity in chronic smokers.

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Figures

Figure 1
Figure 1
Exercise capacity in smokers and nonsmokers with low (<10%) versus high (≥10%) brachial artery flow mediated dilation (FMD). * significantly different than smokers with FMD < 10% (p<0.05). # significantly different than non-smokers with FMD < 10% (p<0.05).
Figure 2
Figure 2
Exercise capacity in smokers and nonsmokers taking statins versus those not taking statins. * significantly different than smokers/statin(-) (p<0.05). # significantly different than non-smokers/statin(-) (p<0.05).
See this image and copyright information in PMC

References

    1. Bernaards CM, Twisk JW, Van Mechelen W, Snel J, Kemper HC. A longitudinal study on smoking in relationship to fitness and heart rate response. Med Sci Sports Exerc. 2003;35(5):793–800. - PubMed
    1. Kobayashi Y, Takeuchi T, Hosoi T, Loeppky JA. Effects of habitual smoking on cardiorespiratory responses to sub-maximal exercise. J Physiol Anthropol Appl Human Sci. 2004;23(5):163–169. - PubMed
    1. Hashizume K, Yamaji K, Kusaka Y, Kawahara K. Effects of abstinence from cigarette smoking on the cardiorespiratory capacity. Med Sci Sports Exerc. 2000;32(2):386–391. - PubMed
    1. Arena R, Myers J, Williams MA, Gulati M, Kligfield P, Balady GJ, et al. Assessment of functional capacity in clinical and research settings: a scientific statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention of the Council on Clinical Cardiology and the Council on Cardiovascular Nursing. Circulation. 2007;116(3):329–343. - PubMed
    1. Paterson DH, Govindasamy D, Vidmar M, Cunningham DA, Koval JJ. Longitudinal study of determinants of dependence in an elderly population. J Am Geriatr Soc. 2004;52(10):1632–1638. - PubMed

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