[Effect of hyperchylomicronemia and hyperprebetalipoproteinemia on the vascular walls of rats of different ages]

Abstract

The effect of hyperchylomicronemia and hyperprebetalipo-proteinemia on the vascular wall of 6--10 and 26--30-month-old rats was studied. These animals were injected intravenously with the blood serum taken from rats, preliminarily treated with Triton WR 1339 (intraperitoneal administration). The electron microscopy study revealed the presence of inclusion of chylomicrons and lipoproteins of very low density in the endothelium of old animals only. Swelling of the Golgi complex and mitochondria, expansion of the cysterns of endoplasmic reticulum in the endothelial cells of young rats pointed to the activation of intracellular metabolic processes. The study under these conditions of the biosynthesis of some lipid classes in the aorta showed a similar inhibition of free cholesterol biosynthesis in rats of various age. An increase of phospholipid biosynthesis was recorded in young animals only.