doi: 10.1021/ol100138k.
A short biomimetic synthesis of the meroterpenoids guajadial and psidial A
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- PMID: 20235528
- DOI: 10.1021/ol100138k
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A short biomimetic synthesis of the meroterpenoids guajadial and psidial A
Org Lett.
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Abstract
The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels-Alder reaction between caryophyllene and an o-quinone methide. This hypothesis has been verified via the biomimetic synthesis of guajadial and psidial A in an aqueous three-component coupling reaction, between caryophyllene, benzaldehyde, and diformylphloroglucinol.
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