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Review
. 1991;19(3):192-8.
doi: 10.1002/mpo.2950190309.

Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia

N X von der Weid  1 , H de Crousaz, D Beck, T Deonna, J Miklossy, R C Janzer
Affiliations
Review

Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia

N X von der Weid et al. Med Pediatr Oncol. 1991.

Abstract

We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support the hypothesis of a direct toxic effect of methotrexate and/or cytosine arabinoside on structures directly exposed to the cerebrospinal fluid.

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