First-spike latency in the presence of spontaneous activity
- PMID: 20235823
- DOI: 10.1162/neco.2010.11-09-1118
First-spike latency in the presence of spontaneous activity
Abstract
A new statistical method for the estimation of the response latency is proposed. When spontaneous discharge is present, the first spike after the stimulus application may be caused by either the stimulus itself, or it may appear due to the prevailing spontaneous activity. Therefore, an appropriate method to deduce the response latency from the time to the first spike after the stimulus is needed. We develop a nonparametric estimator of the response latency based on repeated stimulations. A simulation study is provided to show how the estimator behaves with an increasing number of observations and for different rates of spontaneous and evoked spikes. Our nonparametric approach requires very few assumptions. For comparison, we also consider a parametric model. The proposed probabilistic model can be used for both single and parallel neuronal spike trains. In the case of simultaneously recorded spike trains in several neurons, the estimators of joint distribution and correlations of response latencies are also introduced. Real data from inferior colliculus auditory neurons obtained from a multielectrode probe are studied to demonstrate the statistical estimators of response latencies and their correlations in space.
Similar articles
-
A nonparametric approach for detection of bursts in spike trains.J Neurosci Methods. 2007 Mar 15;160(2):349-58. doi: 10.1016/j.jneumeth.2006.09.024. Epub 2006 Oct 30. J Neurosci Methods. 2007. PMID: 17070926
-
An algorithm for real-time extraction of population EPSP and population spike amplitudes from hippocampal field potential recordings.J Neurosci Methods. 2004 Jul 30;136(2):111-21. doi: 10.1016/j.jneumeth.2004.01.006. J Neurosci Methods. 2004. PMID: 15183263
-
Modelling spike trains and extracting response latency with Bayesian binning.J Physiol Paris. 2010 May-Sep;104(3-4):128-36. doi: 10.1016/j.jphysparis.2009.11.015. Epub 2009 Nov 27. J Physiol Paris. 2010. PMID: 19945532
-
First-spike latency of auditory neurons revisited.Curr Opin Neurobiol. 2004 Aug;14(4):461-7. doi: 10.1016/j.conb.2004.07.002. Curr Opin Neurobiol. 2004. PMID: 15321067 Review.
-
Neuronal coding and spiking randomness.Eur J Neurosci. 2007 Nov;26(10):2693-701. doi: 10.1111/j.1460-9568.2007.05880.x. Eur J Neurosci. 2007. PMID: 18001270 Review.
Cited by
-
Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.J Neurophysiol. 2015 Aug;114(2):1008-21. doi: 10.1152/jn.00357.2015. Epub 2015 Jun 10. J Neurophysiol. 2015. PMID: 26063780 Free PMC article.
-
Subset of thin spike cortical neurons preserve the peripheral encoding of stimulus onsets.J Neurophysiol. 2010 Dec;104(6):3588-99. doi: 10.1152/jn.00295.2010. Epub 2010 Oct 13. J Neurophysiol. 2010. PMID: 20943946 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources