Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010;14(1):122.
doi: 10.1186/cc8228. Epub 2010 Feb 16.

Increased blood flow by insulin infusion targeting normoglycemia in patients with severe sepsis: friend or foe?

Greet Van den Berghe
Comment

Increased blood flow by insulin infusion targeting normoglycemia in patients with severe sepsis: friend or foe?

Greet Van den Berghe. Crit Care. 2010.

Abstract

A small study in patients with severe sepsis suggested that insulin infused to normalize blood glucose levels increased forearm flow. This clinical observation supports the effect of insulin on the endothelium, as previously shown by in vitro studies and by in vivo animal models of critical illness, but the clinical consequences remain unclear.

PubMed Disclaimer

Comment on

References

    1. Žuran I, Poredoš P, Skale R, Voga G, Gabršček L, Parežnik R. Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial. Crit Care. 2009;13:R198. doi: 10.1186/cc8202. - DOI - PMC - PubMed
    1. Dandona P, Aljada A, Mohanty P, Ghanim H, Bandyopadhyay A, Chaudhuri A. Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9. Diabetes Care. 2003;26:3310–3314. doi: 10.2337/diacare.26.12.3310. - DOI - PubMed
    1. Dandona P, Aljada A, Chaudhuri A, Mohanty P. Endothelial dysfunction, inflammation and diabetes. Rev Endocr Metab Disord. 2004;5:189–197. doi: 10.1023/B:REMD.0000032407.88070.0a. - DOI - PubMed
    1. Dandona P, Aljada A, Chaudhuri A, Bandyopadhyay A. The potential influence of inflammation and insulin resitance on the pathogenesis and treatment of atherosclorosis-related complications in type 2 diabetes. J Clin Endocrinol Metab. 2003;88:2422–2429. doi: 10.1210/jc.2003-030178. - DOI - PubMed
    1. Ellger B, Debaveye Y, Vanhorebeek I, Langouche L, Giulietti A, Van Etten E, Herijgers P, Mathieu C, Berghe G Van den. Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes. 2006;55:1096–1105. doi: 10.2337/diabetes.55.04.06.db05-1434. - DOI - PubMed

MeSH terms