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. 2010 Mar 17:2:15.
doi: 10.1186/1758-5996-2-15.

The eSS rat, a nonobese model of disordered glucose and lipid metabolism and fatty liver

Stella M Daniele #  1 , Silvana M Montenegro #  2   3 , María C Tarres #  2   3 , Juan C Picena #  2 , Stella M Martinez  2   3
Affiliations

The eSS rat, a nonobese model of disordered glucose and lipid metabolism and fatty liver

Stella M Daniele et al. Diabetol Metab Syndr. .

Abstract

Background: eSS is a rat model of type 2 diabetes characterized by fasting hyperglycemia, glucose intolerance, hyperinsulinemia and early hypertriglyceridemia. Diabetic symptoms worsen during the second year of life as insulin release decreases. In 12-month-old males a diffuse hepatic steatosis was detected. We report the disturbances of lipid metabolism of the model with regard to the diabetic syndrome.

Methods: The study was conducted in eight 12-month-old eSS male rats and seven age/weight matched eumetabolic Wistar rats fed with a complete commercial diet al libitum. Fasting plasmatic glucose, insulin, triglycerides, total cholesterol, low-density and high-density lipoprotein, and nonesterified fatty acids levels were measured. Very low density and intermediate-density lipoproteins were analyzed and hepatic lipase activity was determined.

Results: eSS rats developed hyperglycemia and hyperinsulinemia, indicating insulin resistance. Compared with controls, diabetic rats exhibited high plasmatic levels of NEFA, triglycerides (TG), total cholesterol (Chol) and LDL-Chol while high-density lipoprotein (HDL) cholesterol values were reduced. eSS rats also displayed TG-rich VLDL and IDL particles without changes in hepatic lipase activity.

Conclusion: The nonobese eSS rats develop a syndrome characterized by glucose and lipid disorders and hepatic steatosis that may provide new opportunities for studying the pathogenesis of human type 2 diabetes.

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