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. 2010 Apr 1;18(7):2611-20.
doi: 10.1016/j.bmc.2010.02.033. Epub 2010 Feb 23.

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

John B Bremner  1 , Paul A Keller, Stephen G Pyne, Timothy P Boyle, Zinka Brkic, Dorothy M David, Mark Robertson, Kittiya Somphol, Dean Baylis, Jonathan A Coates, John Deadman, Darshini Jeevarajah, David I Rhodes
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Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

John B Bremner et al. Bioorg Med Chem. .

Abstract

An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE).

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