Drug discovery: inhibitors that activate
- PMID: 20237552
- DOI: 10.1038/464358a
Drug discovery: inhibitors that activate
Comment on
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.Nature. 2010 Mar 18;464(7287):431-5. doi: 10.1038/nature08833. Epub 2010 Feb 3. Nature. 2010. PMID: 20130576
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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.Nature. 2010 Mar 18;464(7287):427-30. doi: 10.1038/nature08902. Nature. 2010. PMID: 20179705 Free PMC article.
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