Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Sep;15(5):467-77.
doi: 10.1007/s10741-010-9163-9.

Resveratrol and red wine, healthy heart and longevity

Dipak K Das  1 , Subhendu Mukherjee, Diptarka Ray
Affiliations
Review

Resveratrol and red wine, healthy heart and longevity

Dipak K Das et al. Heart Fail Rev. 2010 Sep.

Corrected and republished in

Abstract

Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11836-41 - PubMed
    1. Nature. 2003 Sep 11;425(6954):191-6 - PubMed
    1. Carcinogenesis. 2007 May;28(5):922-31 - PubMed
    1. J Biol Chem. 2005 Apr 29;280(17):17187-95 - PubMed
    1. Biochem Pharmacol. 2005 Jan 1;69(1):41-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources