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. 1991 May 1;88(9):3671-5.
doi: 10.1073/pnas.88.9.3671.

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1

S T Smiley  1 , M Reers, C Mottola-Hartshorn, M Lin, A Chen, T W Smith, G D Steele Jr, L B Chen
Affiliations

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1

S T Smiley et al. Proc Natl Acad Sci U S A. .

Abstract

By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine++ + iodide (JC-1), we find that membrane potentials across mitochondria in a living cell can be heterogeneous. Remarkably, even within a long contiguous mitochondrion, regional heterogeneity in membrane potentials appears to be possible.

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