doi: 10.1016/0092-8674(78)90147-2.
The binding site on SV40 DNA for a T antigen-related protein
- PMID: 202398
- DOI: 10.1016/0092-8674(78)90147-2
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The binding site on SV40 DNA for a T antigen-related protein
Cell.
1978 Jan.
Abstract
A protein closely related to SV40 T antigen was purified in a biologically active form from cells infected with the defective adenovirus-SV40 hybrid, Ad2+D2. This 107,000 dalton hybrid protein binds and protects a specific portion of SV40 DNA from digestion by pancreatic DNAase I. Hybridization, endonuclease cleavage and pyrimidine tract analysis of the protected fragments reveal that the D2 hybrid protein binds in a sequential manner to tandem recognition sites which lie within a sequence of 120 nucleotides at position 67 near the origin of SV40 replication.
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