Role of neurotensin in radiation-induced hypothermia in rats
- PMID: 2023992
Role of neurotensin in radiation-induced hypothermia in rats
Abstract
The role of neurotensin in radiation-induced hypothermia was examined. Intracerebroventricular (ICV) administration of neurotensin produced dose-dependent hypothermia. Histamine appears to mediate neurotensin-induced hypothermia because the mast cell stabilizer disodium cromoglycate and antihistamines blocked the hypothermic effects of neurotensin. An ICV pretreatment with neurotensin antibody attenuated neurotensin-induced hypothermia, but did not attenuate radiation-induced hypothermia, suggesting that radiation-induced hypothermia was not mediated by neurotensin.
Similar articles
-
Involvement of prostaglandins and histamine in radiation-induced temperature responses in rats.Radiat Res. 1990 Jan;121(1):84-90. Radiat Res. 1990. PMID: 2300672
-
Time course of the hypothermic response to continuously administered neurotensin.Neuropeptides. 2007 Oct;41(5):349-54. doi: 10.1016/j.npep.2007.06.002. Epub 2007 Jul 25. Neuropeptides. 2007. PMID: 17655926
-
Cross-fostering does not alter the differential sensitivity of Fischer and Lewis rats to central neurotensin-induced locomotion and hypothermia.Behav Brain Res. 2006 Jul 15;171(1):142-6. doi: 10.1016/j.bbr.2006.03.027. Epub 2006 May 5. Behav Brain Res. 2006. PMID: 16678278
-
Effect of ondansetron and ICS 205-930 on radiation-induced hypothermia in rats.Radiat Res. 1997 Jun;147(6):741-6. Radiat Res. 1997. PMID: 9189174
-
[Neurotensin].Nihon Rinsho. 1983 May;41(5):920-5. Nihon Rinsho. 1983. PMID: 6138447 Review. Japanese. No abstract available.
Cited by
-
Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation.Sci Rep. 2019 Oct 30;9(1):15701. doi: 10.1038/s41598-019-52120-w. Sci Rep. 2019. PMID: 31666611 Free PMC article.
-
The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia.Behav Brain Res. 2011 Oct 31;224(2):344-9. doi: 10.1016/j.bbr.2011.06.014. Epub 2011 Jun 21. Behav Brain Res. 2011. PMID: 21718721 Free PMC article.
-
Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.J Pharmacol Exp Ther. 2016 Feb;356(2):474-82. doi: 10.1124/jpet.115.229872. Epub 2015 Nov 25. J Pharmacol Exp Ther. 2016. PMID: 26606937 Free PMC article.