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. 1991 May;126(2):218-22.

Role of neurotensin in radiation-induced hypothermia in rats

S B Kandasamy  1 , W A Hunt, A H Harris
Affiliations
  • PMID: 2023992

Role of neurotensin in radiation-induced hypothermia in rats

S B Kandasamy et al. Radiat Res. 1991 May.

Abstract

The role of neurotensin in radiation-induced hypothermia was examined. Intracerebroventricular (ICV) administration of neurotensin produced dose-dependent hypothermia. Histamine appears to mediate neurotensin-induced hypothermia because the mast cell stabilizer disodium cromoglycate and antihistamines blocked the hypothermic effects of neurotensin. An ICV pretreatment with neurotensin antibody attenuated neurotensin-induced hypothermia, but did not attenuate radiation-induced hypothermia, suggesting that radiation-induced hypothermia was not mediated by neurotensin.

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