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Comparative Study
. 1991 Mar 29;175(3):914-9.
doi: 10.1016/0006-291x(91)91652-s.

Potent HIV-1 protease inhibitors with antiviral activities in vitro

H L Sham  1 , D A Betebenner, N E Wideburg, A C Saldivar, W E Kohlbrenner, S Vasavanonda, D J Kempf, D W Norbeck, C Zhao, J J Clement, et al.
Affiliations
Comparative Study

Potent HIV-1 protease inhibitors with antiviral activities in vitro

H L Sham et al. Biochem Biophys Res Commun. .

Abstract

A series of novel difluoroketones with low molecular weight (less than 600 m.u.) and which are potent inhibitors of the HIV-1 protease (IC50 = 1.0 to 21 nM) were synthesized. These compounds also exhibited antiviral activity by inhibition of the cytopathic effect of HIV-1(3)B in MT-4 cells in vitro.

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