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. 1991 Apr 30;176(2):622-6.
doi: 10.1016/s0006-291x(05)80229-3.

ATP-dependent transport for glucuronides in canalicular plasma membrane vesicles

K Kobayashi  1 , S Komatsu, T Nishi, H Hara, K Hayashi
Affiliations

ATP-dependent transport for glucuronides in canalicular plasma membrane vesicles

K Kobayashi et al. Biochem Biophys Res Commun. .

Abstract

Using rat liver canalicular plasma membrane vesicles, it has been verified that the transport of p-nitrophenyl glucuronide (NPG) across membranes is an ATP-dependent process; the apparent Km for NPG was 20 microM. S-(2,4-dinitrophenyl)-glutathione (DNP-SG) inhibited NPG uptake dose-dependently, and NPG or testosterone glucuronide did ATP-dependent DNP-SG uptake similarly. These results suggest that transport of glucuronide is mediated by an ATP-dependent glutathione S-conjugate carrier.

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