doi: 10.1016/0014-5793(91)80463-d.
Protein kinase C(19-31) pseudosubstrate inhibition of insulin action in rat adipocytes
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- PMID: 2026249
- DOI: 10.1016/0014-5793(91)80463-d
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Protein kinase C(19-31) pseudosubstrate inhibition of insulin action in rat adipocytes
FEBS Lett.
.
Free article
Abstract
Treatment of intact adipocytes with the autoregulatory PKC pseudosubstrate PKC(19-31) inhibited insulin-stimulated hexose uptake and lipogenesis, with no effect on basal values. The effect was dose-dependent with respective IC50 values of 30 microM and 600 microM for insulin-stimulated hexose uptake in electroporated and intact adipocytes. These studies indicate that PKC may play a role in the mediation of insulin action in adipocytes.
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