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. 1991 Apr 22;282(1):139-42.
doi: 10.1016/0014-5793(91)80463-d.

Protein kinase C(19-31) pseudosubstrate inhibition of insulin action in rat adipocytes

M L Standaert  1 , J Sasse, D R Cooper, R V Farese
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Free article

Protein kinase C(19-31) pseudosubstrate inhibition of insulin action in rat adipocytes

M L Standaert et al. FEBS Lett. .
Free article

Abstract

Treatment of intact adipocytes with the autoregulatory PKC pseudosubstrate PKC(19-31) inhibited insulin-stimulated hexose uptake and lipogenesis, with no effect on basal values. The effect was dose-dependent with respective IC50 values of 30 microM and 600 microM for insulin-stimulated hexose uptake in electroporated and intact adipocytes. These studies indicate that PKC may play a role in the mediation of insulin action in adipocytes.

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