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. 1991 Mar;72(3):451-2.

Stimulation of Ig production and growth of human lymphoblastoid B-cell lines by nerve growth factor

H Kimata  1 , A Yoshida, C Ishioka, H Mikawa
Affiliations

Stimulation of Ig production and growth of human lymphoblastoid B-cell lines by nerve growth factor

H Kimata et al. Immunology. 1991 Mar.

Abstract

The effects of nerve growth factor (NGF) on human lymphoblastoid B-cell lines were studied. NGF increased Ig production and proliferation by lymphoblastoid B-cell lines GM-1500, GM-1056 and CBL in a dose-dependent manner. As little as 0.01 ng/ml of NGF was effective. This effect was blocked by anti-NGF serum but not by control serum. Other cytokines, including interleukin (IL)-1 beta, IL-2, IL-4, IL-5, interferon (IFN)-alpha, IFN-beta, IFN-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF), did not stimulate Ig production. These results indicate that, in addition to its neurotropic effect NGF also acts as B-cell stimulatory factor.

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