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Comparative Study
. 1991 Feb;29(2):64-6.

The influence of various drugs on the binding of tianeptine to human plasma proteins

R Zini  1 , D Morin, C Salvadori, J P Tillement
Affiliations
  • PMID: 2026465
Comparative Study

The influence of various drugs on the binding of tianeptine to human plasma proteins

R Zini et al. Int J Clin Pharmacol Ther Toxicol. 1991 Feb.

Abstract

The plasma binding of the atypical tricyclic antidepressant tianeptine was studied in combination with six drugs, at therapeutic concentrations: cyamemazine, levomepromazine, flunitrazepam, oxazepam, diclofenac and salicylic acid. Of these drugs, only salicylic acid at high plasma concentrations impaired tianeptine binding and thus may potentiate its effects.

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