doi: 10.1093/jnci/60.2.401.
Rescue of a transforming virus from a spontaneous nonproducing osteosarcoma in BALB/c mice
- PMID: 202717
- DOI: 10.1093/jnci/60.2.401
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Rescue of a transforming virus from a spontaneous nonproducing osteosarcoma in BALB/c mice
J Natl Cancer Inst.
1978 Feb.
Abstract
Cells from spontaneous osteosarcoma V793 that originated in a 19-month-old female BALB/c mouse were cultured. They did not produce a C-type oncovirus as determined by extracellular reverse transcriptase assay and cytoplasmic immunofluorescence. After cocultivation with Balb/3T3 cells chronically infected with a murine leukemia virus (MuLV), a focus-forming principle that transformed 3T3 cells, secondary BALB/c mouse embryo and WAG/Rij rat embryo fibroblasts were rescued. The transformation could be inhibited by antiserum to MuLV.
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