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. 1978 Feb;60(2):401-3.
doi: 10.1093/jnci/60.2.401.

Rescue of a transforming virus from a spontaneous nonproducing osteosarcoma in BALB/c mice

P Bentvelzen, K Nooter, B F Deys

Rescue of a transforming virus from a spontaneous nonproducing osteosarcoma in BALB/c mice

P Bentvelzen et al. J Natl Cancer Inst. 1978 Feb.

Abstract

Cells from spontaneous osteosarcoma V793 that originated in a 19-month-old female BALB/c mouse were cultured. They did not produce a C-type oncovirus as determined by extracellular reverse transcriptase assay and cytoplasmic immunofluorescence. After cocultivation with Balb/3T3 cells chronically infected with a murine leukemia virus (MuLV), a focus-forming principle that transformed 3T3 cells, secondary BALB/c mouse embryo and WAG/Rij rat embryo fibroblasts were rescued. The transformation could be inhibited by antiserum to MuLV.

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