doi: 10.1093/jnci/60.2.461.
Oncogenicity of murine mammary tumor virus produced in tissue culture: brief communication
- PMID: 202721
- DOI: 10.1093/jnci/60.2.461
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Oncogenicity of murine mammary tumor virus produced in tissue culture: brief communication
J Natl Cancer Inst.
1978 Feb.
Abstract
Murine mammary tumor virus (MuMTV), produced from a glucocorticoid-stimulated C3H mouse mammary adenocarcinoma cell line, was free of murine leukemia virus and oncogenic for weanling BALB/c mice. Adenocarcinomas were induced by MuMTV as early as 136 days post inoculation and with as low as 5 X 10(3) virus particles/mouse. Tumor incidence did not correlate directly with virus dose; rather, it was low at higher MuMTV concentrations (1.2 X 10(8) particles/mouse), reached and optimum at 1.3 X 10(5) particles/mouse, and decreased with virus dilution.
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