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Comparative Study
. 1991;103(2):162-5.
doi: 10.1007/BF02244197.

Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart

E W Larson  1 , M A Pfenning, E Richelson
Affiliations
Comparative Study

Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart

E W Larson et al. Psychopharmacology (Berl). 1991.

Abstract

Seven antimuscarinic compounds, used mostly for the treatment of extrapyramidal problems, were tested in vitro in radioligand binding assays for evidence of selectivity for two different pharmacological subtypes of the human muscarinic receptor, M1, a predominant form in brain, and M2, a predominant form in heart. Although biperiden, scopolamine, procyclidine, and benztropine showed significant selectivity in the in vitro assays, it is likely that in clinical practice biperiden would be the drug of choice to avoid any antimuscarinic effects on the heart.

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References

    1. J Neurochem. 1984 Aug;43(2):299-302 - PubMed
    1. Nature. 1980 Jan 3;283(5742):90-2 - PubMed
    1. J Neurochem. 1986 Jan;46(1):274-9 - PubMed
    1. Biochem Pharmacol. 1985 Feb 15;34(4):588-90 - PubMed
    1. Trends Pharmacol Sci. 1989 Dec;Suppl:11-5 - PubMed

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