[Fatty acid composition of rat liver chromatin fractions under conditions of stimulation of lipid peroxidation]

Abstract

The residues of non-saturated fatty acids being the substrates of lipids peroxidation in chromatin are introduced to the composition of fractions of transcriptionally active and repressed chromatin of rat liver. The amount of non-saturated fatty acids is higher in transcriptionally active chromatin fraction as compared to their amount in the repressed fraction which correlated with the level of lipids peroxidation in these fractions under its activation in vitro. Stimulation of lipids peroxidation in vivo as a result of a single administration of tetrachloroethane and under E-avitaminosis results in the expressed shift of fatty -acid composition of the both chromatin fractions: the amount of substrate lipid peroxide oxidation increases in its repressed part and decrease in its transcriptionally active part. Administration of ionol antioxidant does not result in any noticeable normalization of the shift of fatty-acid composition of chromatin evoked by the lipids peroxidation.