Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Nov 25;18(1):29-32.
doi: 10.1007/BF00215276.

Studies of poly(A+)-RNA in mouse hepatoma and cortisone-stimulated rat liver

I M Konstantinova, V A Kulichkova, V I Vorob'ev, E A Ratovitski, J D Shaposhnikov

Studies of poly(A+)-RNA in mouse hepatoma and cortisone-stimulated rat liver

I M Konstantinova et al. Mol Cell Biochem. .

Abstract

The content of poly(A)-containing RNA in subcellar fractions has been investigated both in cortisone-treated rat liver and experimental hepatoma cells. The fractions included nuclei, cytoplasm, mitochondria, free and membrane-bound polyribosomes. 1) In both cases of genome activation (cortisone induction and hepatoma cells) an increase in poly(A) content of all subcellular fractions except free polyribosomes was observed. 2) Cortisone was found to induce elongation of poly(A) segments detected in both nuclei and cytoplasm. 3) An increase in the poly(A) block size also was found to be stimulated in nuclei and cytoplasm of hepatoma cells. 4) The observed elongation in poly(A) length occurred against the background of an increase of the population of of poly(A)-RNA's.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Biochemistry. 1975 Jul 29;14(15):3445-51 - PubMed
    1. Biochem Biophys Res Commun. 1972 Nov 1;49(3):680-9 - PubMed
    1. Mol Cell Biochem. 1975 Aug 30;8(2):123-8 - PubMed
    1. J Cell Biol. 1973 Jan;56(1):191-205 - PubMed
    1. J Biol Chem. 1960 Apr;235:1142-9 - PubMed