Case Reports
Origin of estrogen in isosexual precocious pseudopuberty due to a granulosa-theca cell tumor
- PMID: 202898
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Case Reports
Origin of estrogen in isosexual precocious pseudopuberty due to a granulosa-theca cell tumor
Obstet Gynecol.
1978 Feb.
Abstract
The purpose of the present study was to quantify the rates of production and to define the mechanism(s) or origin of sex steroid hormones in a 3 1/2-year-old girl with isosexual precocious pseudopuberty caused by a granulosa-theca cell tumor of the ovary. The results suggest that the hyperestrogenism occurs principally due to the secretion of estradiol-17beta synthesized de novo by the tumor, but that the tumor in vivo was also capable of aromatizing C19 plasma precursor hormones to estrogen.
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