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. 1977 Dec;4(12):4261-77.
doi: 10.1093/nar/4.12.4261.

The sv40 transcription complex. I. Effect of viral chromatin proteins on endogenous RNA polymerase activity

T L Brooks, M H Green
Free PMC article

The sv40 transcription complex. I. Effect of viral chromatin proteins on endogenous RNA polymerase activity

T L Brooks et al. Nucleic Acids Res. 1977 Dec.
Free PMC article

Abstract

SV40 chromatin obtained from infected monkey cells was used to study the effect of the viral chromatin proteins on endogenous RNA polymerase II. Ammonium sulfate activated the rate of transcription by endogenous RNA polymerase in two ways: 1) by direct action on the enzyme; and 2) by causing a reversible conformational change in the viral chromatin. Under optimal reaction conditions, the viral chromatin proteins did not limit the rate of RNA chain elongation, and high molecular weight RNA (1.6 X 10(6) d) was synthesized by the SV40 chromatin.

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References

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