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. 2010 Apr 20;26(8):5309-11.
doi: 10.1021/la100712y.

Phospholipid complexation of general anesthetics in fluid bilayers

Serhan Turkyilmaz  1 , Hideyuki Mitomo, Wen-Hua Chen, Steven L Regen
Affiliations

Phospholipid complexation of general anesthetics in fluid bilayers

Serhan Turkyilmaz et al. Langmuir. .

Abstract

A nearest-neighbor recognition analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a fundamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC forms 1:1 complexes with CHCl(3) in both membranes in the fluid bilayer state.

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Figures

Chart 1
Chart 1
Figure 1
Figure 1
Reaction vessel used for carrying out NNR and binding measurements.
Figure 2
Figure 2
Plots of (a) K and (b) ωAB as a function of membrane-bound CHCl3/phospholipid (mol/mol) in cholesterol-rich, lo (■) and cholesterol-poor, ld (□) bilayers. Error bars that are not visible lie within the symbols themselves. The highest ratio in each series were obtained under saturation conditions.
Figure 3
Figure 3
A stylized illustration showing the insertion (i.e., “drilling”) of two CHCl3 molecules into a segment of a cholesterol-rich monolayer and simultaneous filling in of void space.
See this image and copyright information in PMC

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