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. 1991 Feb;20(2):167-73.
doi: 10.2165/00003088-199120020-00007.

Effects of posture and sleep on the pharmacokinetics of paracetamol (acetaminophen) and its metabolites

R H Rumble  1 , M S Roberts, M J Denton
Affiliations

Effects of posture and sleep on the pharmacokinetics of paracetamol (acetaminophen) and its metabolites

R H Rumble et al. Clin Pharmacokinet. 1991 Feb.

Abstract

The effects of posture and sleep on the pharmacokinetics of paracetamol (acetaminophen) 500 mg and its metabolites were studied in 8 healthy men. The mean residence times for paracetamol or its metabolites were significantly altered by change in posture or by sleep, whereas other pharmacokinetic parameters were unchanged. The change in mean residence time is consistent with a faster absorption of paracetamol during ambulation. The present data suggest that the proposed posture-related changes in volume of distribution do not exist, and that there is no pharmacokinetic basis for a headache being relieved by taking paracetamol and lying down.

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