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Editorial
. 2010 Mar 23;55(12):1237-1239.
doi: 10.1016/j.jacc.2009.11.053.

Understanding radiation-induced vascular disease

Neal L Weintraub  1 , W Keith Jones  2 , David Manka  3
Affiliations
Editorial

Understanding radiation-induced vascular disease

Neal L Weintraub et al. J Am Coll Cardiol. .

Abstract

Radiation injury of blood vessels was originally described more than a century ago and remains a contemporary clinical problem, despite dramatic advances in the field of radiation oncology (1). Clinical studies indicate that patients who have previously undergone radiation therapy for various malignancies—such as lymphoma, breast cancer, and head and neck cancer—are at increased risk for developing vascular disease (2). The consequences are significant; depending upon the study, the relative risk of suffering a clinical cardiovascular event (i.e., myocardial infarction, stroke) related to radiation therapy ranges from approximately 1.5- to 4.0-fold, and this risk is further amplified in the presence of traditional cardiovascular risk factors (3,4).

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Figures

Figure 1
Figure 1. Proposed Mechanism of Involvement of NF-κB in Radiation-Induced Vascular Disease
NF-κB = nuclear factor-kappa B.
See this image and copyright information in PMC

Comment on

References

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