Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jun;5(6):1107-13.
doi: 10.2215/CJN.08721209. Epub 2010 Mar 18.

The spectrum of MYH9-associated nephropathy

Meredith A Bostrom  1 , Barry I Freedman
Affiliations
Review

The spectrum of MYH9-associated nephropathy

Meredith A Bostrom et al. Clin J Am Soc Nephrol. 2010 Jun.

Abstract

Causes of the excess incidence rates of chronic kidney disease in the African American population have long been under study. Recently, polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) have been associated with nondiabetic kidney diseases in African- and European-derived populations. Risk variants in MYH9 contribute to approximately 70% of nondiabetic forms of ESRD in African Americans and 40 to 45% of all ESRD in this ethnic group, with lesser effects in European Americans. It is clear that MYH9 polymorphisms have a significant impact on the incidence rates of kidney disease in African Americans. This article describes the current spectrum of biopsy-proven MYH9-associated kidney diseases, along with potential effects of MYH9 on ethnic differences in clinical outcome. MYH9 risk variants exhibit the most impressive association with any common complex kidney disease yet identified.

PubMed Disclaimer

Figures

Figure 1
Figure 1
MYH9 structure and location of the E-1 haplotype SNPs. The first 40 kb of MYH9, with exons in boxes and the promoter regions in gray, is shown. The location of the four SNPs that make up the E-1 haplotype are indicated. Gene structure was developed using Haploview (52) with infotrack downloaded from http://www.hapmap.org.
Figure 2
Figure 2
Proposed pathogenesis of MYH9-associated nephropathy.
Figure 3
Figure 3
The spectrum of MYH9-associated nephropathy.
See this image and copyright information in PMC

References

    1. Freedman BI, Iskandar SS, Appel RG. The link between hypertension and nephrosclerosis. Am J Kidney Dis. 1995;25:207–221. - PubMed
    1. Freedman BI, Sedor JR. Hypertension-associated kidney disease: Perhaps no more. J Am Soc Nephrol. 2008;19:2047–2051. - PubMed
    1. Zarif L, Covic A, Iyengar S, Sehgal AR, Sedor JR, Schelling JR. Inaccuracy of clinical phenotyping parameters for hypertensive nephrosclerosis. Nephrol Dial Transplant. 2000;15:1801–1807. - PubMed
    1. US Renal Data System . USRDS 2008 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; Bethesda: 2008.
    1. Shulman NB, Ford CE, Hall WD, Blaufox MD, Simon D, Langford HG, Schneider KA. Prognostic value of serum creatinine and effect of treatment of hypertension on renal function: Results from the hypertension detection and follow-up program. The Hypertension Detection and Follow-up Program Cooperative Group. Hypertension. 1989;13:I80–I93. - PubMed

Publication types

MeSH terms